The intent of this paper is to reveal the must know current trends and perspectives in countering Human Immunodeficiency Virus Infection amp Acquired Immuno deficiency Syndrome HIVAIDS locally and globally. The different perspectives include physical interventions pharmacological interventions psychobehavioural interventions social interventions and interventions related to vocation plus finances to enhance amp sustain the quality of life of people living with HIVAIDS in terms of wellbeing. The aim of this paper was to unveil the new strategies in dealing with prevention and control of HIVAIDS with efforts to elevate the sense of negativity and manifest the acceptable or affordable living standards of people diagnosed with HIVAIDS