International trade has become a major threat to biodiversity in the telecoupled world. The literature on biodiversity loss mostly concentrates on wild species; however, the increasing loss of and demand for domesticated species are overlooked. Donkeys are decreasing in many countries because of economic development, urbanization, and increased demand for donkey hides in China. The donkey population in Africa has rapidly declined recently due to supplying China with donkey hides for the production of highly demanded and legalized traditional medicine, ejiao. As a result, some African countries, including Botswana, banned the export of donkey hides. Animal protection and media continuously reported threats over the extinction of donkeys and exacerbated rural livelihood in developing countries, however, limited literature has investigated the causes and effects of donkey-hide trade and its policy interventions. This paper applies the telecoupling framework and uses the data extracted from the media reports and FAO, to understand the scale and impacts of donkey-hide trade from Botswana to China. We also explore the challenges and opportunities of donkey-hide trade for Botswana, highlighting the mechanisms need to be established to regulate the donkey-hide trade, and also to harness available opportunities if the trade ban is lifted in the future.