Background: Sublingual allergy immunotherapy (AIT) has been proven in meta-analyses to reduce both symptoms and medication use in asthma. Objective: To assess safety and efficacy of sublingual immunotherapy as add on treatment for 6 months on asthmatic children. Patients and Methods:In a randomized controlled study, we did this study at Department of Pediatrics at Zagazig University Hospitals, during the period from May 2019 to October 2019. It included 60 children who have mild to moderate persistent asthma symptoms according to (GINA guide lines 2015) confirmed with skin prick test for positive allergen sensitivity. Sixty asthmatic children were categorized in two groups (30 children, each): Group A: received only the standard treatment of asthma, Group B: received specific sublingual immunotherapy (SLIT) with the standard treatment of asthma. Results: After receiving SLIT treatment, total IgE was significantly lower than before treatment with improvement in pulmonary functional parameters in SLIT group. The SLIT group showed significant increase in control of asthma after six months of treatment with SLIT. There was a significant decrease in using medications after receiving SLIT group. Conclusion: Clinical evidence supports the use of SLIT for the treatment of asthma in children. Reduces allergic asthma symptoms and the need for medication.

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Background: Vitamin D is a vital component of bone metabolism and calcium homeostasis, and its deficiency is known to cause rickets, osteomalacia and hypocalcemia. Objective: The aim of this study was to evaluate vitamin D level in patients with nephrotic syndrome and its relation to calcium.

Background: The aim of this study was to investigate the role of Neopterin in evaluation of severity and outcome of pneumonia in pediatric Department of Zagazig University Hospitals. Methods: A prospective case control study was carried out at the pediatric Department of Zagazig University Children Hospitals during the period from November 2017 to December 2018 .sixty infants and children patients participated in the study 40 were diagnosed as pneumonia admitted to Pediatric Department of Zagazig University as case group And twinty infants and children of control. Serum level of Neopterin was measured for all patients recruited in this study, by a commercial ELISA assay. Results: In our study there was statistically significant difference between case and control groups in Neopterin level, there is statistically significant difference in Neopterin level between cases that need ICU admission and M.V. and cases treated in ward only without need , there was statistically significant difference in Neopterin level between survivors and non-survivors. In this study, there was statistically significant difference in Neopterin level with disease severity.in which Neopterin is higher in severe than moderate and mild cases. Our study shows that there was statistically significant positive correlation between Neopterin level and total PRESS score, granulocytes and CRP. In our study we tried to detect the cutoff point of Neopterin to detect severe pneumonia calculated from ROC curves it was > 13.93 (nmol/L), and the area under the curve of Neopterin was0.866 with sensitivity 92.3% and specificity 77.8%. Conclusion: Neopterin is a useful prognostic and diagnostic marker for pneumonia in Pediatrics. The present study suggests that Neopterin is a promising biomarker for reflecting the severity of Pneumonia.