This article examines efforts to safeguarding genetic resources, traditional knowledge, and regular cultural expressions (GRTKTCE) within the Association of Southeast Asian Nations (ASEAN). It considers ASEAN's legal frameworks and its intellectual property rights action plan on the issue. Also, it discusses challenges in protecting GRTKTCE at the ASEAN level. Mainly, it discusses Indonesia's position, legislation, and policies on the issue. GRTKTCE is one of the characteristics and elements of ASEAN Economic Community Blueprint 2025. It seems that ASEAN is fully committed to working together on this issue. In the broader multilateral level, that is the World Trade Organization and the World Intellectual Property Organization forum, the issue of GRTKTCE has been negotiated for quite a long time. However, the issues still face challenges over its basic concept, including a concept of commercialization and how it could work in practice. This article constitutes initial research findings of the writer's Ph.D. thesis. It covers the legal frameworks, impetus, administration, and implementation of intellectual property rights and GRTKTCE within ASEAN and Indonesia.

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