Pulmonary artery intimal sarcoma is a rare disorder arising from the intima of the pulmonary artery. Histopathology reveals that it is a tumour cell of mesenchymal origin. The signs and symptoms include chronic shortness of breath and other features of right ventricular failure, which mimic chronic pulmonary thromboembolism. The definitive diagnosis can rarely be made based on the symptoms and signs alone, and other investigations including echocardiography, computed tomography, magnetic resonance imaging (MRI), and positron emission tomography (PET) are often required. The gold standard for diagnosis is tissue biopsy. The mainstay for treatment is surgery, and complete surgical resection with endarterectomy provides survival benefit. According to recent evidences, however, multimodal treatment provides better survival outcomes than monotherapy such as surgery alone. Despite the newer upcoming treatment strategies, patients with pulmonary intimal sarcoma continue to have a poor prognosis. We present a case of pulmonary artery intimal sarcoma and review the literature associated with the disease.

In this work, a preliminary numerical simulation of the lower urinary system using Computational Fluid Dynamics (CFD) is performed. Very few studies have been done on the simulation of three-dimensional urine through the lower urinary system. In this study, a simplified lower urinary model with rigid body assumption is proposed. The distributions of urine flow velocity, wall pressure and shear stress along the urethra are simulated based on MRI scanned uroflowmetry of a normal female. Numerical results show that violent secondary flows appear on the cross surface near the end of the urethra when the inflow rate is increased. The oscillative variation of pressure and shear stress distributions are found around the beginning section of the urethra when flow rate is at the peak value.

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