The antibacterial efficiency and
synergistic mechanisms of novel
formulated eugenol entrapped ethosome nanoparticles (ELG-NPs) against
fruit anthracnose were investigated. The results showed that concentrations
of eugenol and ethanol significantly influenced the particle size
and entrapment efficiency of nanoethosome, and the particle size significantly
influenced the antibacterial effect. Superior ELG-NPs with optimized
process (0.5% eugenol, 2% lecithin, and 30% ethanol) were obtained
with a size of 44.21 nm and entrapment efficiency of 82%. ELG-NPs
exhibited an antibacterial activity (>93%) against fruit pathogens
that was greater than that of free eugenol and showed 100% inhibition
of the anthracnose incidence in postharvest loquat after 6 d. The
permeability study, first visualized in banana cortex with fluorescent
indicators, demonstrated that eugenol delivered to the interior with
ELG-NPs was 6-fold higher than that of free eugenol. ELG-NPs showed
a satisfactory slow-release and prolonged antibacterial action. This
work provides a promising strategy for disease controls in agricultural,
food, cosmetic, and medical areas.
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