Organic−inorganic halide perovskite solar cells (PSCs) have received particular attention in the last decade because of the high−power conversion efficiencies (PCEs), facile fabrication route and low cost. However, one of the most crucial obstacles to hindering the commercialization of PSCs is the instability issue, which is mainly caused by the inferior quality of the perovskite films and the poor tolerance of organic hole−transporting layer (HTL) against heat and moisture. Inorganic HTL materials are regarded as promising alternatives to replace organic counterparts for stable PSCs due to the high chemical stability, wide band gap, high light transmittance and low cost. In particular, nanostructure construction is reported to be an effective strategy to boost the hole transfer capability of inorganic HTLs and then enhance the PCEs of PSCs. Herein, the recent advances in the design and fabrication of nanostructured inorganic materials as HTLs for PSCs are reviewed by highlighting the superiority of nanostructured inorganic HTLs over organic counterparts in terms of moisture and heat tolerance, hole transfer capability and light transmittance. Furthermore, several strategies to boost the performance of inorganic HTLs are proposed, including fabrication route design, functional/selectively doping, morphology control, nanocomposite construction, etc. Finally, the challenges and future research directions about nanostructured inorganic HTL−based PSCs are provided and discussed. This review presents helpful guidelines for the design and fabrication of high−efficiency and durable inorganic HTL−based PSCs.