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Children with ependymoma have high mortality rates because ependymoma is resistant to conventional therapy. Genomic and transcriptomic studies have identified potential targets as significantly altered genes in ependymoma patients. Although several candidate oncogenes in ependymoma were recently reported, the detailed mechanisms for the roles of these candidate oncogenes in ependymoma progression remain unclear. Here, we report an oncogenic role of the nucleoporin TPR (translocated promoter region, nuclear basket protein) in regulating HSF1 (heat shock transcription factor 1) mRNA trafficking, maintaining MTORC1 activity to phosphorylate ULK1, and preventing macroautophagy/ autophagy induction in ependymoma. High expression of TPR were associated with increased HSF1 and HSPA/HSP70 expression in ependymoma patients. In an ependymoma mouse xenograft model, MTOR inhibition by rapamycin therapeutically suppressed TPR expression and reduced tumor size in vivo. Together, these results suggest that TPR may act as a biomarker for ependymoma, and pharmacological interventions targeting TPR-HSF1-MTOR may have therapeutic potential for ependymoma treatment.

Incidence of drug overdose during treatment of acute disease consequently leads to serious renal damage. As supporting treatment, administration of herbal medicine and food dietary are frequently developed. This research aimed to prove how the administration of avocado juice could lower the BUN and creatinine level in white rats induced with toxic doses of meloxicam. Meloxicam is a non-steroidal anti-inflamatory drug (NSAID), which is effectively used as an anti-inflamatory, analgesic, and antipyretic. Twenty four (24) male Wistar rats were assigned to 4 groups of six rats each (n=6). 1 ml of CMC 1% was administered to Control Group I, 30 mg/kgBB meloxicam and 1 ml of CMC 1% to Control Grup II, 30 mg/kgBB meloxicam and avocado juice 5 g/kgBB/day to Treatment Group I, and 30 mg/kgBB meloxicam and avocado juice 10 g/kgBB/day to Treatment Group II. The study was conducted over 8 days, then the level of Blood Urea Nitrogen and creatinine of the white rats were examined on the 1st and 8th day. The results were analyzed by Anova Two Way With Replication, then followed by T-test (α = 0,05) if there were difference. The Anova Two Way With Replication test showed that the mean of the four groups either the levels of Blood Urea Nitrogen or creatinine was significantly decreased (p<0,05). The decrease of BUN in the treatment group I was 27,17 27,17mg/dl and 17,83mg/dl while the decrease of creatinine level was 0,983mg/dl and 0,713mg/dl. The conclusion of this study was that avocado juice decreases level of Blood Urea Nitrogen and creatinine in white rats which exposed toxic doses of meloxicam.

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