dari ibu diabetes mellitus (IDM) memiliki risiko lebih tinggi mengalami berbagai morbiditas pada masa neonatus. Metabolisme bilirubin merupakan salah satu sistem yang mungkin terganggu. Tujuan. Mengetahui faktor risiko hiperbilirubinemia pada bayi IDM dan hubungannya dengan faktor risiko hiperbilirubinemia yang lain. Metode. Studi kohort retrospektif pada 71 IDM dan 71 bayi ibu tidak diabetes melitus (ITDM) yang lahir di RSUP Dr.Sardjito antara Januari 2007 -Desember 2014. Data diperoleh dari register neonatal-perinatal WHO-SEARO. Hasil. Risiko hiperbilirubinemia lebih tinggi pada bayi IDM dibandingkan ITDM (42% vs 17%) (RR=2,5 IK95% 1,4-4,5). Analisis stratifikasi menunjukkan bahwa risiko dipengaruhi oleh usia kehamilan, berat lahir, polisitemia, dan inisiasi menyusu dini. Sepsis meningkatkan risiko pada IDM (RR=11,5 IK95% 3,7-36,0), sedangkan inisiasi menyusu dini merupakan faktor pencegah (RR=0,6, KI 95% 0,3-0,9). Kesimpulan. Ibu diabetes melitus meningkatkan risiko hiperbilirubinemia pada masa neonatus. Risiko ini dipengaruhi oleh berat lahir, usia kehamilan, kondisi sepsis, dan inisiasi menyusu dini. Sari Pediatri 2016;18(1):6-11Kata kunci: bayi baru lahir, ibu diabetes melitus, hiperbilirubinemia Risk Factors for Hyperbilirubinemia in Infants of Diabetic MothersDio R.Biade, Tunjung Wibowo, Setya Wandita, Ekawaty L. Haksari, Madarina Julia Background. Infants of diabetic mothers (IDM) have higher risk for morbidities in neonatal period, including problems due to bilirubin metabolism. Objective. To assess the risk for hyperbilirubinemia in IDM and its associations with other risk factors for hyperbilirubinemia. Methods. Retrospective cohort study on 71 IDM and 71 infants of non-diabetic mother (NIDM) who were born at Dr. Sardjito hospital between January 2007 and December 2014. Data were collected from the WHO-SEARO Neonatal -Perinatal Database. Results. Hyperbilirubinemia was more common in IDM than in NIDM (42% vs 17%), RR=2.5, 95%CI 1.4 to 4.5. Further stratification showed that risk for hyperbilirubinemia was modified by birth weight, gestational age, sepsis, polycythemia and initial breastfeeding. Sepsis increased risk for hyperbilirubinemia, i.e. combined RR (95%CI) of 11.5 (3.7-36.0). Initial breastfeeding protected IDM from hyperbilirubinemia (RR= 0.6, 95%CI 0.3 to 0.9). Conclusion. Infants of diabetic mothers has increased risk for hyperbilirubinemia. The risk is modified by birth weight, gestational age, sepsis and initial breast feeding. Sari Pediatri 2016;18(1):6-11