BackgroundThere are a large number of assessment tools for tinnitus, with little consensus on what it is important to measure and no preference for a minimum reporting standard. The item content of tinnitus assessment tools should seek to capture relevant impacts of tinnitus on everyday life, but no-one has yet synthesised information about the range of tinnitus complaints. This review is thus the first comprehensive and authoritative collection and synthesis of what adults with tinnitus and their significant others report as problems in their everyday lives caused by tinnitus.MethodsElectronic searches were conducted in PubMed, Embase, CINAHL, as well as grey literature sources to identify publications from January 1980 to June 2015 in which participants were enrolled because tinnitus was their primary complaint. A manual search of seven relevant journals updated the search to December 2017. Of the 3699 titles identified overall, 84 records (reporting 86 studies) met our inclusion criteria and were taken through to data collection. Coders collated generic and tinnitus-specific complaints reported by people with tinnitus. All relevant data items were then analyzed using an iterative approach to narrative synthesis to form domain groupings representing complaints of tinnitus, which were compared patients and significant others.ResultsFrom the 86 studies analyzed using data collected from 16,381 patients, 42 discrete complaints were identified spanning physical and psychological health, quality of life and negative attributes of the tinnitus sound. This diversity was not captured by any individual study alone. There was good convergence between complaints collected using open- and closed-format questions, with the exception of general moods and perceptual attributes of tinnitus (location, loudness, pitch and unpleasantness); reported only using closed questions. Just two studies addressed data from the perspective of significant others (n = 79), but there was substantial correspondence with the patient framework, especially regarding relationships and social life.ConclusionsOur findings contribute fundamental new knowledge and a unique resource that enables investigators to appreciate the broad impacts of tinnitus on an individual. Our findings can also be used to guide questions during diagnostic assessment, to evaluate existing tinnitus-specific HR-QoL questionnaires and develop new ones, where necessary.Trial RegistrationPROSPERO registration number: CRD42015020629. Protocol published in BMJ Open. 2016;6e009171.Electronic supplementary materialThe online version of this article (10.1186/s12955-018-0888-9) contains supplementary material, which is available to authorized users.

Objective: Tinnitus is associated with various conditions such as presbycusis, infectious, autoimmune and many other diseases. Our study aims to identify an association between inflammatory markers and the presence of tinnitus or hearing loss (HL).Design: Exploratory study including a structured interview, complete ENT observation, audiological and inflammatory markers evaluation.Study Sample: 60 women and 54 men (55 to 75 years) from the Portuguese population, with or without sensory presbycusis and/or tinnitus.Results: IL10 levels were significantly lower in participants with tinnitus than in those without tinnitus. Moreover, TGF-β was lower in older participants (p=.034), IL1α was higher in participants with tonal tinnitus (p=.033), and IL2 was lower in participants who reported partial or complete residual inhibition (p=.019). Additionally, we observed a negative correlation between tinnitus duration and IL10 levels (r=-.281), and between HSP70 levels and tinnitus loudness (r=-.377). TNF-α and HSP70 levels appears to be sensitive to the time when samples were collected (i.e. morning or afternoon). Conclusions:The results of our study show fluctuations in inflammatory markers along the hearing loss process, reinforce the idea that inflammatory mechanisms are involved in hearing loss pathogenesis but also in tinnitus. IL10 levels appear significantly altered in tinnitus but not hearing loss.

Introduction: Presbycusis or age-related hearing loss (ARHL) is a ubiquitous health problem. It is estimated that it will affect up to 1.5 billion people by 2025. In addition, tinnitus occurs in a large majority of cases with presbycusis. Glutamate metabotropic receptor 7 (GRM7) and N-acetyltransferase 2 (NAT2) are some of the genetic markers for presbycusis.Objectives: To explore patterns of hearing loss and the role of GRM7 and NAT2 as possible markers of presbycusis and tinnitus in a Portuguese population sample.Materials and Methods: Tonal and speech audiometry, tinnitus assessment, clinical interview, and DNA samples were obtained from patients aged from 55 to 75 with or without tinnitus. GRM7 analysis was performed by qPCR. Genotyping of single nucleotide polymorphisms (SNPs) in NAT2 was performed by PCR amplification followed by Sanger sequencing or by qPCR.Results: We screened samples from 78 individuals (33 men and 45 women). T allele at GRM7 gene was the most observed (60.3% T/T and 33.3% A/T). Individuals with a T/T genotype have a higher risk for ARHL and 33% lower risk for tinnitus, compared to individuals with A/A and A/T genotype, respectively. Being a slow acetylator (53%) was the most common NAT2 phenotype, more common in men (55.8%). Intermediate acetylator was the second most common phenotype (35.9%) also more frequent in men (82.6%). Noise exposed individuals and individuals with ‘high frequency’ hearing loss seem to have a higher risk for tinnitus. Our data suggests that allele AT of GRM7 can have a statistically significant influence toward the severity of tinnitus.Conclusion: For each increasing year of age the chance of HL increases by 9%. The risk for ARHL was not significantly associated with GRM7 neither NAT2. However, we cannot conclude from our data whether the presence of T allele at GRM7 increases the odds for ARHL or whether the A allele has a protective effect. Genotype A/T at GRM7 could potentially be considered a biomarker of tinnitus severity. This is the first study evaluating the effect of GRM7 and NAT2 gene in tinnitus.

reference lists from relevant systematic reviews and the included primary studies; citation searching of the included primary studies using Web of Science; and hand searching the last six months of key otology journals.Inclusion criteria: Human subjects with subjective tinnitus. Searches were limited to articles in the English language, published in peer reviewed journals.Exclusion criteria: Animal studies, objective tinnitus, Ménières disease, Otosclerosis, Chronic otitis media, history of oncology and chemotherapy, ototoxic drugs intake, autoimmune diseases, neurodegenerative or demyelinating disease.Results: All stages of the study were carried out by at least two members of the review team. The titles and abstracts of the studies identified through the initial search has yielded 3801 records, after removel of duplicates and exclusion based on defined criteria 79 records were selected and the full text articles was requested. Data were extracted using a data extraction form which was developed for purpose and piloted prior to its use. Any disagreements were resolved through discussion or consultation with the third member of the review team. Extracted data included participant information (demographics, baseline characteristics, sample size), country, control, study design,research question, tinnitus characteristics (type of sound, constancy, severity [measure used]), genes and/or biological factor assessed, and key data and findings, conclusions. Pooled estimates (or narrative synthesis) of the association between biological factors and presence or severity of tinnitus from individual studies will be presented.

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