Avascular necrosis of bone is a well-described complication of cancer chemotherapy containing corticosteroids, and has been observed in lymphomas and acute lymphoblastic leukemia. Avascular necrosis occurring in association with neuroblastoma has never been reported before. This study reports on a 7-year-old boy with stage IV neuroblastoma developing avascular necrosis of the femoral head of both hips during treatment with combination chemotherapy using cyclophosphamide, cisplatin, etoposide, and doxorubicin. He was given conservative treatment in view of the progressive disease.