A b s t r a c t A r t i c l e I n f oThe aim of this study was green synthesis of silver nanoparticles by using mint plant leaves extracts and to evaluate their antimicrobial activity. The fresh suspension of plant extracts was yellowish-green in colour. However, after addition of AgNO 3 within 20mins, the suspension showed change in colour and turned dark brown after 5 hrs of incubation at room temperature. Formation of silver nanoparticles was confirmed using UV-Vis spectral analysis and showed silver surface plasmon resonance band in the range of 200-600 nm. It is a well-known fact, that silver ions and nanoparticles are highly toxic and hazardous to microorganisms. It is found out that the silver nanoparticles have many inhibitory and bactericidal effects and so its application is extended as an antibacterial agent. The antibacterial activity of silver nanoparticles is estimated by the zone of inhibition. The silver nanoparticles biosynthesized by mint plant leaves extracts showed antibacterial activity against microorganisms Escherichia coli, Pseudomonas aeruginosa, Baccillus subtilis (Gram Negative) and Staphylococcus aureus (Gram Positive). However, the antimicrobial effect varied with the variation in salt concentration. Additionally, the silver nanoparticles by mint plant leaves extracts showed good inhibition activity towards Escherichia coli and Pseudomonas aeruginosa. The use of silver nanoparticles in drug delivery systems might be the future thrust in the field of medicine.

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In both developed and emerging economies, carcinoma is one of the most frequent malignancies. Non-small cell lung cancer accounts for 80% of all melanoma within India. The basic concept of molecular precision medicine for lung cancer is the EGFR (Epidermal growth factor receptor), which belongs to the tyrosine kinase receptor family (RTKs). Garlic (Allium sativum L), an Indian Traditional spice from the Allium family, appears to be capable of inhibiting cancer cell formation through an apoptotic route. In the present research, the competence and binding ability of various phytochemical compounds from garlic targeting lung melanoma marker protein were assessed. Garlic's medicinal benefits are assumed to be due to key components within the elemental composition, such as organosulfur compounds and flavonoids. There were 19 compounds along with 2 reference compounds that were used for molecular docking purposes. The study revealed that the chemicals investigated are bound effectively to EGFR. When compared to water-soluble and lipid-soluble organosulfur compounds, garlic flavonoids had the anticipated free energy of interaction. Especially in contrast to Alliin, S-Methyl-L-cysteine, Kaempferol, Quercetin, Myrecetin, Apigenin along with Erlotinib demonstrated excellent interaction. Alliin, the much more prevalent component throughout the whole garlic bulb, has a stronger affinity via intermolecular hydrogen bonding, with a binding energy of -7.4 kcal/ Mol. The water-soluble chemical S-Methyl-L-cysteine also had positive interactions with EGFR (-7.3 Kcal/mol). Among the flavonoid groups studied, Quercetin, Myrecetin and Apigenin were found to be the best suitable compound with a binding energy of -8.5 kcal/ Mol. The current findings pave the way for a deeper understanding of garlic's active substance interactions with EGFR. The substances discovered might be utilised as a prototype for anti-cancer treatmentHowever, more research into these compounds' biochemical functions is required before they can be used to treat lung cancer.

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