Background: Typhoid and paratyphoid remain common bloodstream infections in areas with suboptimal water and sanitation infrastructure. Paratyphoid, caused by Salmonella Paratyphi A, is less prevalent than typhoid and its antimicrobial resistance (AMR) trends are less documented. Empirical treatment for paratyphoid is commonly based on the knowledge of susceptibility of Salmonella Typhi, which causes typhoid. Hence, with rising drug resistance in Salmonella Typhi, last-line antibiotics like ceftriaxone and azithromycin are prescribed for both typhoid and paratyphoid. Here, we report 23-year AMR trends of Salmonella Paratyphi A in Bangladesh. Methods: From 1999 to 2021, we conducted enteric fever surveillance in two major pediatric hospitals and three clinics in Dhaka, Bangladesh. Blood cultures were performed at the discretion of the treating physicians; cases were confirmed by culture, serological and biochemical tests. Antimicrobial susceptibility was determined following CLSI guidelines. Results: Over 23 years, we identified 2,725 blood culture-confirmed paratyphoid cases. Over 97% of the isolates were susceptible to ampicillin, chloramphenicol, and cotrimoxazole, and no isolate was resistant to all three. No resistance to ceftriaxone was recorded, and >99% of the isolates were sensitive to azithromycin. A slight increase in minimum inhibitory concentration (MIC) is noticed for ceftriaxone but current average MIC is 32-fold lower than the resistance cut-off. Over 99%, of the isolates exhibited decreased susceptibility to ciprofloxacin. Conclusions: Salmonella Paratyphi A has remained susceptible to most antibiotics, unlike Salmonella Typhi, despite widespread usage of many antibiotics in Bangladesh. The data can guide evidence-based policy decisions for empirical treatment of paratyphoid fever.

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In Bangladesh, the 2019 coronavirus disease (COVID-19) pandemic has already resulted in 1.52 million cases of sickness and 26,794 deaths by 2021-09-09. As a result of hormonal and physiological shifts, pregnant women may be more vulnerable to life-threatening lung infections. During 2019 coronavirus disease (COVID-19) pandemic, scientists sought to thoroughly analyze the available literature on the link between SARS-CoV-2 infections and pregnancy. This study's primary objective was to evaluate the literature about the consequences of SARS-related CoV-2 on pregnancy. We have collected the data for this meta-analysis by searching PubMed, Scopus, Medline, the Cochrane database, Google Scholar, and the reference lists of all included papers. We used the PRISMA criteria to evaluate the abstracts of the published research articles. After ensuring data consistency, only sources and materials useful to the study's objectives were used. We have completed our review of the literature and have included 23 sarticles in our analysis.

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Introduction: Ectopic pregnancy is the implantation of a fertilized egg in a location outside of the uterine cavity, including the fallopian tubes, cervix, ovary, cornual region of the uterus, and the abdominal cavity. Objective: To evaluate the sonological findings of ectopic pregnancy. Materials and Methods: A descriptive study was carried out at ultrasound unit in Lab-Aid diagnostic, Comfort Medical Services and Green View Diagnostic Complex in Sylhet city between January 2012 to January 2014. We included all cases with confirmed diagnosis of ectopic pregnancy, all antenatal mothers who are present in antenatal unit in a selected Hospital and excluded mothers with other associated medical condition. Results: Common clinical pattern were shock, marked pallor ness, abdominal pain, amenorrhea and irregular vaginal bleeding 52%, 66%,62%,54% and 38% respectively. Risk factor of ectopic pregnant in this study, 40% had history of infertility, 06% had Non tuberculous PID, 70% had no risk factor, 04% had tuberculous PID, 14% had previous abdominal pelvic surgery, 18% had previous ectopic and 10% had endometriosis. Conclusion: Common clinical pattern were shock, marked pallor ness, abdominal pain, amenorrhea and irregular vaginal bleeding. History of infertility, Non tuberculous PID, no risk factor, tuberculous PID, previous abdominal pelvic surgery, previous ectopic and endometriosis were risk factor of ectopic pregnant in this study. Medicine Today 2022 Vol.34(1): 75-78