Low-temperature scanning tunneling microscopy was used to follow the formation of a solvation shell around an adsorbed functionalized azo dye from the attachment of the first water molecule to a fully solvated molecule. Specific functional groups bind initially one water molecule each, which act as anchor points for additional water molecules. Further water attachment occurs in areas close to these functional groups even when the functional groups themselves are already saturated. In contrast, water molecules surround the hydrophobic parts of the molecule only when the two-dimensional solvation shell closes around them. This study thus traces hydrophilic and hydrophobic properties of an organic molecule down to a sub-molecular length scale.

Short and efficient syntheses of mono-and tris-functionalized resorcin[4]arenes were developed. The co-condensation of resorcinol and 2-methylresorcinol was optimized, targeting for the trimethylresorcin[4]arene, easy to isolate. Complementary regiospecific conditions for the mono-and tris-halo-Universitätsstraße 150,

Low-temperature scanning tunneling microscopy was used to follow the formation of asolvation shell around an adsorbed functionalizeda zo dye from the attachment of the first water molecule to af ully solvated molecule.S pecific functional groups bind initially one water molecule each, which act as anchor points for additional water molecules. Further water attachment occurs in areas close to these functional groups even when the functional groups themselves are already saturated. In contrast, water molecules surround the hydrophobic parts of the molecule only when the twodimensional solvation shell closes around them. This study thus traces hydrophilic and hydrophobic properties of an organic molecule down to asub-molecular length scale.

The Cover Feature shows the simplified three‐step synthesis of mono‐ and tri‐functionalized resorcin[4]arenes, with the central structure as one target molecule. Circumventing the first step statistical product mixture – illustrated in the background – by utilizing the significant different product solubilities, led to easy manageable binary mixtures. Complementary regiospecific conditions for the bromination of the trimethyl‐resorcinarene were applied, resulting in high‐yield syntheses of potential building blocks for supramolecular chemistry. More information can be found in the Full Paper by G. Dyker et al.