Background: Practising the use of antibiotics in emergency surgeries drastically reduces the incidence of post-operative systemic and surgical site infections. There are very few articles about the details of use of antibiotics in abdominal trauma. We studied the effect of preliminary drugs therapy against bacteria in patients with abdominal trauma. Methods: From Ma    y 2020 to May 2021, we looked back and surveyed the medical files of patients with abdominal trauma in our institution, Krishna institute of medical sciences deemed to be university, Karad. Blunt and piercing abdominal injuries were included in our study Results: Data of the 432 patients were accumulated. Antibiotic was initiated in 96.4% of penetrating injury and 79.7% with blunt injury. Initial antibiotics therapy was provided to 78.2% of patients with solid organ injury and 97.5% with hollow viscus injury. On an average of 6 days, antibiotics were given in solid organ injuries, 6.2 days in hollow viscus. Infection within 2 weeks of admission occurred in 50 cases. Infection linked severity of injury, surgery performed and blood transfused. Time for which the antibiotic was given did not affect the rate of infection. Conclusion: It was inferred that the antibiotics were used in massive numbers (84.2%) and for prolonged time (6.2 days) in these patients in Karad.