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A large group of patients with psychotic illness were in remission without the use of antipsychotic medication, peaking at year 10. Overall there was a large degree of stability in disease courses over the 10-year period. These results suggest that the long-term outcome of psychotic illness is heterogeneous and further investigation on a more individualized approach to long-term treatment is needed.

Summary It is estimated that eight percentage of all acute medical admissions are due to adverse drug reactions, and three percentage of all approved new medical entities are later withdrawn from the market due to safety issues. Adverse drug reactions are of public health concern and this paper reviews five selected adverse drug reaction scandals that all caused significant stir and had a huge impact on our way of thinking, drug development and legislation.

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