We investigated the outcomes of Ivermectin-Doxycycline vs. Favipiravir therapy in mild to moderate COVID19 patients. Methods: Patients were divided randomly into two groups: Ivermectin 200µgm/kg single dose + Doxycycline 100mg BID for ten days in group A, and Favipiravir 1800mg for the first day, then 800mg BID for six days in group B (Control group). RT-PCR for SARS-CoV-2 infection was repeated in all symptomatic patients on the second day onward without symptoms. Repeat PCR was done every two days onward if the result found positive. Time to the negative PCR and symptomatic recovery was measured for each group. Results: All subjects in Group A reached a negative PCR, at a mean of 8.93 days, and reached symptomatic recovery, at a mean of 5.93 days, with 55.10% symptom-free by the fifth day. In group B, 96.36% reached a negative PCR at a mean of 9.33 days and were symptoms-free at 6.99 days. In group a 31.67% of patients expressed symptoms caused by medication, this was 46.43% in group B. Conclusion:The combination therapy of Ivermectin-Doxycycline showed a trend towards superiority to the combination of Favipiravir for mild to moderate COVID19 disease.

Background: Sputum smear negative pulmonary tuberculosis is a common problem faced by clinicians. Fiberoptic bronchoscopy may be very useful in diagnosing these cases which have no sputum or whose sputum smear is negative for acid fast bacilli. Objective of the current study was to assess the role of fiberoptic bronchoscopy in sputum smear negative under NTEP and radiologically suspected cases of pulmonary tuberculosis.Methods: Clinico-radiological suspected cases of pulmonary tuberculosis patients in whom two sputum smear for acid fast bacilli by Ziehl Neelsen stain under NTEP was negative were included in the study. Fiberoptic bronchoscopy was performed in all these patients and samples taken were sent for investigations.Results: Fiberoptic bronchoscopy was performed in 250 patients of suspected pulmonary tuberculosis whose sputum for AFB smear was negative. Cough was the most predominant symptom. Radiologically, right side disease was more common and upper zone was most commonly involved and infiltrates were common radiological finding. During bronchoscopy, congestion and hyperaemia (36%) and mucopurulent/mucoid secretions (32%) was seen in maximum number of cases. BAL was positive in 200 patients (80%), post bronchoscopy sputum was positive in 70 cases (28%) and biopsy was positive in 12 patients out of 16 performed biopsies (75%). The total TB positive cases after combining all the methods were 215 making the overall diagnostic yield of 86%.Conclusions: Fiberoptic bronchoscopy and post bronchoscopy sputum can be very useful for diagnosing sputum for AFB smear negative but clinico-radiological suspected cases of pulmonary tuberculosis patients.

Background: Asthma is a chronic and common inflammatory disease involving mainly large airways of lungs. Childhood asthma is common chronic illness among school going children and is usually underdiagnosed and undertreated. The aim of the present study was to find out of the prevalence of Bronchial asthma in school going children of age group 6-12 years in southern part of Rajasthan (India), and its relation with gender, socio-economic status and heredity.Methods: A questionnaire-based study has been carried out in 1500 children of 6 to 12 years age group in four schools of Udaipur city (Rajasthan, India) with a response rate of 60.23% (904/1500).Results: The overall prevalence of asthma observed is 4.75% (43/904). The prevalence is higher among boys (5.55%) as compared to girls (3.75%). Further the prevalence is higher in upper (7.18%) and upper middle class (7.14%) children as compared to lower middle (4.84%) and upper lower class (2.01%) socioeconomic status. The children with positive family history of asthma also have higher prevalence (26.31%) of asthma.Conclusions: The prevalence of childhood asthma in Udaipur city is relatively lower and supports the already reported relation with gender, socioeconomic status and heredity.

Background: We are observing a very tough time once again fighting an invisible enemy, the novel coronavirus. A novel coronavirus spill over event, with its epicenter in Wuhan, China, has emerged as a public health emergency as an international concern today. Chest computed topography and investigating the role of inflammatory mediators plays an important role in evaluation of covid-19 and effective therapy for this infection. Materials and Methods: An observational study in patients of covid-19 admitted in Geetanjali medical college, Udaipur. After taking all necessary consent, patients were enrolled. In each patient: symptom onset, blood and radiological investigations were compared during and after covid-19 treatment. Result: In our study, 68 patients were enrolled, out of which 36 were males and 32 were females. 52 patients were aged above 60 years out of which 50 patients were having co-morbid conditions (DM, HTN, Hypothyroidism, obesity and CAD). Out of the total 68 patients included in our study, 60 patients showed deranged inflammatory markers (CRP, D-Dimer, and Lymphocytes) for more than 45 days amongst these patients. In 39 patients fibrotic changes were observed after three months in chest radiography. Conclusion:From our study we conclude that the positive predictor of pulmonary fibrosis in covid19 infection are old age, co-morbid conditions, high severity index and inflammatory markers.