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The objective of this study is to explore the polarimetric phenomenology of light interaction with healthy and early-stage lung cancer tissue samples by applying efficient polarimetric backscattering detection techniques combined with polarimetric exploratory data analysis. Preliminary results indicate that enhanced discrimination signatures can be obtained for certain types of early-stage lung cancers based on their depolarization, backscattered intensity and retardance characteristics.

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Some benzothiazole derivatives bearing piperazine and dithiocarbamate moieties were synthesized in order to investigate their anticancer activity. The structures of the obtained compounds were confirmed by spectral data and elemental analysis. Synthesized compounds were evaluated for their anticancer activity at the National Cancer Institute against a panel of approximately 60 different human tumor cell lines derived from nine neoplastic cancer types. Compound 3f was found to be significantly active against all cancer types in single concentration assay and selected for second step which includes five concentration assays. In the second step, it exhibited very significant activity on melanoma (LOX IMVI) cell line.