Background: Wound occurs when integrity of the skin is compromised. Healing of wounds occur in various phases namely hemostasis, inflammation, proliferation, granulation, contracture remodelling. Neolamarckia cadamba leaves had been used by the tribal people for the treatment of wounds. Objectives: To formulate a gel of Neolamarckia cadamba which contains carbopol 934 as a gelling agent and to determine its wound healing activity by topical application of gel of Neolamarckia cadamba on surgically induced wounds in Swiss albino mice. Materials and Methods: To study the wound healing properties, free radical scavenging activity by DPPH, nitric oxide, total phenolic content estimation, antibacterial activity, excision and incision studies and histopathology were done. Ethyl acetate fraction of methanolic leaves extract of Neolamarckia cadamba (EAFNC) was applied topically as a 2% gel. Percentage of wound contraction and tensile strength was determined in excision and incision wound model respectively. Results: The animals treated with EAFNC showed significant percentage inhibition of nitric oxide and DPPH as compared to ascorbic acid. Antibacterial activity of EAFNC against Bacillus subtilis and Pseudomonas aeruginosa was also seen. Also, there was increase in wound contraction on 12 th post wounding day (81.33 ± 0.574), tensile strength (4.645 ± 0.1345). Histopathology of regenerated skin of EAFNC showed prominent collagen networks, mononuclear cells and fibroblasts. Conclusion: The ethyl acetate fraction of methanolic leaves extract of Neolamarckia cadamba (EAFNC) showed significant increase in wound healing activity validating its use by the tribal people.
Objective:The present study was to investigate the antiasthmatic potential from the flavonoid fraction of Apium leptophyllum fruit (FFALF) to validate its traditional claim.Materials and Methods:The antiasthmatic activity of FFALF was evaluated by histamine or acetylcholine-induced bronchospasm model in guinea pigs, compound 48/80 induced mast cell degranulation in albino rats and histamine-induced tracheal contraction in guinea pig. The preconvulsion dyspnea time at 0th and 7th day at the dose of 100 and 200 mg/kg in guinea pig's bronchospasm model, the percentage of granulated and degranulated mast cell at the dose of 500, 750, and 1000 μg/ml in rats and tracheal contraction at the dose of 500, 750, and 1000 μg/ml in guinea pig were measured and compared with respective control groups.Results:The treatments of FFALF were significantly (P < 0.001) decreased the histamine/acetylcholine-induced bronchospasm, mast cell degranulation, and histamine-induced tracheal contraction as compared to inducer group. In addition, FFALF showed dose-dependent antiasthmatic activity in all the animals.Conclusion:Hence, this study suggested that the FFALF showed antiasthmatic activity probably by membrane stabilizing property as well as suppressing antibody production and inhibiting of antigen induced by histamine and acetylcholine.
Through an ethnographic research in the resettlement colonies of Delhi, India, the present study aims to address the effect of the judicial pronouncements in the lives of the evicted population with main focus on the women residing in such colonies. This study aims to understand from the perspective of the various judgements and the victims of evictions, the healing effect it has had on the victims if any. An analysis of the shifting jurisprudence in case of the urban poor will help us better understand the gaze with which they are seen. Also, whether women and issues of violence and violation of rights of women are understood, expressed, prevented and healed or not needs to be understood.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.