Background: Intestinal parasitic diseases are one of the general medical conditions in numerous networks, especially among youngsters in country spaces of agricultural nations. Ethiopian studies have concentrated on the commonness and circulation of 2 intestinal parasitic contaminations, fundamentally among younger students. A couple of studies have looked at the scope on knowledge of under-five children’s mothers regarding the prevention of parasitic infections. Methods: A community-based cross-sectional examination with a quantitative methodology was conducted from November 30 to December 30, 2020, among mothers of under-five children in Bule Hora town. The example size in this investigation was 403. The information will be coded, checked sent out to SPSS Statistics rendition 25 for investigation. Result: The general information and practice level concerning mothers of under-five kids in regards to counteraction of intestinal parasitic contaminations was, all among 51.6 % had poor knowledge and 53.1 % had poor practice. Nearly 50% of children not washing of hands and legs after a play in the soil and more than 55% of mothers not advising the child to wear footwear outside the home. Remaining all aspect shows considerably good practice from mother’s mention. In the Ethnic group, Oromo (AOR 2.199, 95% CI 1.05-4.59) people had good knowledge, mothers who not ready to peruse and compose (AOR 0.26, 95% CI 0.12-0.57) had poor knowledge than others. Further in age group (31-35) (AOR 2.94, 95% CI 1.38-6.24) had a good practice, Amara (AOR 0.39, 95% CI 0.18-0.85) people had poor practice and mothers who not able to read and write (AOR 3.97, 95% CI 1.26-12.49) had good practice than other educated.Conclusion: Mothers with children under the age of five have a considerably low degree of optimal awareness and experience when it comes to preventing intestinal parasitic infection. As a result, campaigns or formal training can be used to raise community consciousness about intestinal parasitic invasion counteraction and control.