Background:
Heterocyclic compounds containing nitrogen have been known to possess a very important
role in the field of medicinal chemistry. Indole and its derivatives displayed a wide range of biological
properties such as anti-inflammatory, analgesic, anti-microbial, anti-convulsant, antidepressant, anti-diabetic,
antihelmintic and anti-allergic activities etc. The diverse biological activities exhibited by compounds containing
indole moiety has provided the impetus to explore its anti-microbial activity in order to save the valuable
life of patients.
</P><P>
Objective: The review focuses on the advances in the synthesis of indole derivatives and antimicrobial
properties exhibited by them.
Conclusion:
A great deal of work has been done in order to synthesize indole derivatives and to evaluate antimicrobial
potential, as indicated by the review. The information provided in this article may be helpful for the
researchers for the development of efficient antimicrobial drugs.
Heterocyclic chemistry is the only branch of chemistry that has applications in
varied areas such as dyes, photosensitizers, coordination compounds, polymeric materials,
biological, and many other fields. Quinoline and its derivatives have always engrossed
both synthetic chemists and biologists because of their diverse chemical and pharmacological
properties as these ring systems can be easily found in various natural products, especially
in alkaloids. Among alkaloids, quinoline derivatives i.e. quinolinium salts have
attracted much attention nowadays owing to their diverse biological profile such as antimicrobial,
antitumor, antifungal, hypotensive, anti-HIV, analgesics and anti-inflammatory,
etc. Quinoline and its analogs have recently been examined for their modes of function in
the inhibition of tyrosine kinases, proteasome, tubulin polymerization, topoisomerase, and
DNA repair. These observations have been guiding scientists for the expansion of new quinoline derivatives
with improved and varied biological activities. Quinolinium salts have immense possibilities and scope to investigate
these compounds as potential drug candidates. Therefore, we shall present a concise compilation of
this work to aid in present knowledge and to help researchers explore an interesting quinoline class having medicinal
potential.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.