INTRODUCTION Dengue is an acute mosquito-borne viral infection that places a significant socioeconomic and disease burden in India. 1,2 Classic dengue fever (DF) is defined by the World Health Organization as an acute febrile illness with two or more of the following signs or symptoms: intense headache , retro-orbital pain, myalgia, arthralgia, rash, leukopenia and hemorrhagic manifestations. The clinical severity of disease has a wide spectrum, and according to the World Health Organization (WHO) dengue classification scheme, there are four grades ranging from uncomplicated dengue fever (DF) to dengue hemorrhagic fever (DHF) and devastating dengue shock syndrome (DSS). DHF is currently defined by the following four World Health Organization (WHO) criteria:  Fever or recent history of fever lasting 2-7 days  Any hemorrhagic manifestation.