Depression is an ordinary mental health care problem and the usual cause of disability worldwide. The main purpose of this research was to determine that how depression affects the life of an individual. It is a leading cause of morbidity and death. Over the last 50–60 years, large numbers of studies published various aspects including the impact of depression. The main purpose of this research is to determine whether the person is suffering from depression or not. The dataset of Depression has been taken from the Kaggle website. Guided Machine Learning classifiers have helped in the highest accuracy of a dataset. Classifiers like XGBoost Tree, Random Trees, Neural Network, SVM, Random Forest, C5.0, and Bay Net. From the result, it is evident that the C5.0 classifier is giving the highest accuracy with 83.94 % and for each classifier, the result is derived based without pre-processing.