Objectives Medication nonadherence is a growing concern globally, and little is known about the adherence of stroke patients. To know the proportion of adherence and nonadherent stroke patients to their medication. To identify factors associated with adherence and nonadherence in stroke patients.Methods A cross-sectional study for the 76 eligible stroke patient ≥18 years old recruited from outpatient stroke clinic from Brunei Neuroscience Stroke and Stroke Rehabilitation Centre (BNSRC). Medication adherence was measured by self-administered scoring. Fisher's exact test was applied to identify associated factors with adherence and nonadherence. Key findings 10.5% of the participants was not adherent to their medication in a selfreported questionnaire. With the use of Fisher's exact test, adherence is associated with exercise (P = 0.034), knowledge on hypertensive medications (P < 0.001), hyperlipidemia medications (P = 0.001), diabetes medications (P < 0.001) and stroke medication (P = 0.004), avoid side effects of medications (P = 0.028), felt depressed or sad (P = 0.001).Conclusions The high adherence rates in this study may be due to the good facilities of Brunei healthcare system, patients' increased concerns about their health, good education provided regarding their medications and family members in reminding them to take their medications.