The structure of heterochromatin protects genome from undesirable
recombinations, while estrogen and luteinizing-releasing hormone (LHRH) cause
changes in structure of chromatin. The objective of this study was to prove
the connection of neonatally applied estrogen and LHRH, with shown effects on
chromatin in hippocampus of adult male rats. Stereological results have shown
that total surface of neuron area in estrogen treated animals significantly
reduced in regard to the control group as well as groups treated with LHRH.
The number of heterochromatin granules in either estrogen or LHRH treated
groups significantly increased, while in the last fourth group treated with
both estrogen and LHRH the difference is even more expressed, both in regard
to the control group and other groups. [Projekat Ministarstva nauke Republike
Srbije, br. 173034]
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