The purpose of the study: to develop an emergent approach to the strategy of anti-epidemic preparedness of healthcare organizations, commensurate with existing and projected epidemiological challenges. Materials and methods. The work uses a comprehensive epidemiological research method with the analysis of materials from the World Health Organization, the Federal Service for Supervision of Consumer Rights Protection and Human Well-being, etc. Results. Proposals have been developed to improve preparedness to respond to epidemiological emergencies of medical organizations (taking into account the facts of deconstruction of the international biosafety system). Conclusion. The modern epidemiological reality is formed by three manifest processes and situations: the dominant COVID-19 pandemic, local outbreaks (sporadic cases) of ubiquitous and evolving infections, as well as new epidemiological risks of anthropogenic genesis, deconstruction of the international system of biological safety and preparedness for measures to respond to biological threats. In these conditions, an emergent approach to the formation of a strategy for anti-epidemic provision of the population in the segment of providing him with therapeutic and preventive care is relevant, the key link of which should be a federal specialized scientific and practical medical center with an educational and training module, providing training for various groups of medical and non-medical specialist. An important direction of the emergent approach is the study of new characteristics of the ecosystems of the epidemic process. The concept of research is proposed as a two-level system that includes the improvement of clinical care and operational analysis of changes in the clinical course and epidemiology of infectious diseases, as well as analyzing the effectiveness and sufficiency of anti-epidemic measures. Keywords: infectious diseases, epidemiology, emergence, prevention.