The article analyzes the confrontation between the United States and China in the Asia-Pacific region, which could lead to the transformation of the global and regional architecture of international relations and weaken the transatlantic partnership of the United States and the European Union in the region. The study identifies the main factors, primarily economic, affecting the balance of power in the region. The attempt of the USA to preserve and strengthen its influence in the region by creating military-political bloc in order to exert pressure on China is highlighted. The article also examines Russia’s foreign policy interests in the Asia-Pacific region, in the context of its interaction with Vietnam.