Introduction: The high world prevalence of rhinosinusitis (RS) initiates the ways of a favorable search for effective and safe medicines for its pathogenetic treatment. The important part of this process is the choice of the most comfortable dosage form, which will enhance therapeutic compliance and ensure the appropriate medicine efficacy and safety. Aim: To substantiate the efficacy of a new nasal spray with anti-inflammatory properties containing Enisamium Iodide (EI) at a concentration of 10 mg/mL by histomorphological study of the nasal cavity and paranasal sinuses mucosal in rabbits with experimental rhinosinusitis (ERS). Methods: EI (nasal spray) was a test object. Sinupret ® was a reference drug. ERS was induced in rabbits on the first day of the study by tamponade of the right half of the nasal cavity under general anesthesia. The study was performed using 24 rabbits (4 groups, 6 rabbits in each group). The histomorphological examination was performed on the 25 th day of the study by the standard light microscopy methods. Results: The histomorphological examination of EI 10 mg/mL (nasal spray) impact on RS in rabbits, which administered during 10 days intranasally, revealed the significant therapeutic effect presented by reduced inflammation signs in the epithelium of the nasal cavities and paranasal sinuses mucosal. Besides, the EI impact was not inferior to the reference drug Sinupret ® in tablets. The study of the pharmacological properties of the EI (nasal spray) on ERS showed the high rate of onset of EI actions when used intranasally which was superior to the rate of actions of the reference drug Sinupret ® (tablets) administered intragastrically. Conclusion: The EI (nasal spray) is a promising drug for a pathogenetic therapy of acute RS, which demands further pre-clinical and clinical studies aiming to substantiate its implementation to the clinical practice.

The existing system of studying forensic medicine in higher medical schools in Ukraine is analyzed by the author. Based on their own experience of scientific and practical work, the authors came to the conclusion that this system needs to be adjusted. According to the authors, the adjustment should include a reorientation of the teaching of forensic medicine to students to study the most necessary amount of theoretical material that is necessary for the practical work of a specialist in the field of forensic medicine during investigative actions. The authors propose to consider mastering these practical skills as the main goal of studying forensic medicine at the undergraduate stage.

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Background: There are different approaches to the assessment of the severity of trauma in a victim and to the provision of specialized health care. Some of them are based on the development of scales and logistic models, using expert systems or statistical methods, to assess the severity of injury and the probability of a particular outcome. This article presents the results of a study on the feasibility of developing and applying various statistical models in order to predict the outcome in the case of different types of trauma, based on data on the status of victims with severe trauma. Patients and methods: