Background:
Prediabetes, defined as impaired glucose tolerance and/or impaired fasting glucose, is
a risk factor for future type 2 diabetes, dyslipidemia, cardiovascular disease and all cause mortality. High serum
levels of ischemia modified albumin (IMA) and malondialdehyde (MDA) as oxidative stress markers were
determined in diabetes, however no studies have investigated these markers together in prediabetes. The aim of
the present study was to investigate the circulating levels of both IMA and MDA in a cohort of prediabetic
adults. The possible associations between both markers and atherogenic index of plasma (AIP) were also
evaluated.
Methods:
This study enrolled 100 adults with prediabetes and 50 healthy controls matched for age and sex.
Anthropometric measurements, fasting and 2-hour post load glucose, glycosylated hemoglobin (A1c), lipids
profile, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), high sensitivity Creactive protein (hs-CRP), AIP, IMA and MDA were assessed.
Results:
IMA, MDA, hs-CRP and AIP were significantly higher in adults with prediabetes than in healthy
controls. Male gender, fasting and post load glucose, A1c, fasting insulin, TGs, HDL-C, hs-CRP, AIP and MDA
were independent predictor variables of IMA, whereas male gender, WC, fasting and post load glucose, A1c,
fasting insulin, TC, TGs, LDL-C, HDL-C, hs-CRP and AIP were independent predictor variables of MDA.
Conclusion:
The elevation of IMA concomitantly with MDA reflecting the antioxidant status in prediabetes,
and their associations with hs-CRP and AIP should reinforce the idea of screening and treatment of prediabetes.