The study aimed to investigate the effect of amlodipine on Sex hormones and sperm parameters in white male rats. The study was conducted in the animal house of the College of Pharmacy/University of Karbala, And on October 31, 2021 until January 30, 2022. Twenty (20) adult white rats, a three-month-old male, with weights ranging from (300-200) g. Male rats were randomly divided into two main groups, the first group was a control group that included (10) rats, It was dosed orally and daily with physiological saline solution (NaCl 0.09%), As for the second group, it was dose it  orally the amlodipine at a concentration of (10 mg/kg) for 60 day. study showed a significant decrease (P≤ 0.01) in the sperm concentration in the caudal epididymis  And in the percentage of live sperm in the caudal epididymis  and sperm motility as well as in the viability of sperm, Also, there was a significant increase (P≤ 0.01) in the percentage of upnormal sperms in the caudal epididymis when compared to the control group. The results of the current study showed a significant decrease (P≤0.01) (P≤0.05) for (Follicle-Stimulating hormone (FSH) and Luteinizing hormone (LH) and Testosterone hormone).