Background: Despite increased attention to more intensive medical therapy for patients with established coronary artery disease (CAD), the presence of type 2 diabetes mellitus (T2DM) is associated with extended vascular atherosclerotic lesions in sites unrelated to the revascularized segment leading to an increased tendency to postrevascularization target and nontarget vessel ischemic events. Material and Methods:We report a case of a 66-year-old man with insulin dependent type 2 diabetes patient who has been admitted to the emergency department for an ischemic event: atypical chest pain after physical exertion.The Aim of the Study: to evaluate the risk factors associated with repeat revascularization within 7 years of first percutaneous coronary intervention (PCI) in a diabetic patient.Results: On initial evaluation the patient presented with the symptoms of atypical chest pain, confined in the epigastrium, dyspnea.The physical findings of the patient: atrial fibrillation, hypotension, type 2 diabetes with macro-and microangiopathy, chronic kidney disease (CKD), hyperlipidemia, previous revascularization by PCI were revealed. The recent coronary angiography showed multivessel atherosclerotic lesions in sites unrelated to the previously revascularized segments. Conclusion:The obtained data suggest that the factors associated with repeat revascularization within 7 years of first percutaneous coronary intervention of the presented case are uncontrolled type 2 diabetes mellutis, CKD, dyslipidemia and the progression of atherosclerosis with the involvement of multivessel legions.