Abstract. Codling moth (Cydia pomonella L.) is one of the most important apple pests which population is steadily growing. The aim of this study, conducted in Eastern Croatia, was to determine the efficiency of two biological preparations CpGV and kaolin clay compared with pyrethroids and control treatment. The preparations used in treatments were: 1) Cydia pomonella granulovirus (CpGV), 2) deltamethrin, beta cyfluthrin and alpha-cipemetrina, 3) kaolin, 4) control treatment, applying in two different methods of time control, on the three apple varieties 'Melrose', 'Jonagored' and 'Golden Delicious' clone B. The efficiency of the treatment 1 (CpGV) ranged from 78% to 95%, of treatment 2 (pyrethroids) from 96% to 97%, and treatment 3 (kaolin) -between 21.5 and 57%. There was significant negative correlation between yield and damage (r = −07.56). Two methods of determining time control did not differ significantly. Variety 'Melrose' had the highest number of fruits damage in all three years and 'Golden Delicious' clon B the lowest number which can be related to the codling moth caterpillar affinity to a certain variety. It is very important to make the best choice of preparations in control and at the same time be sure of their positive effect on the environment and human health.