This phase II trial demonstrates that 2-CdA is an effective antilymphocyte, antineoplastic agent with significant activity as a single agent in patients with recurrent or refractory low-grade lymphocytic lymphoma. Responses were achieved with an acceptable toxicity profile. Further trials of this agent in previously untreated patients and in combination regimens are indicated and will be developed.

S the first case and to date, after 3 months, this is the only region showing similar changes in studies of the second patient. An agent, immunologically identified as measles virus has been isolated from one of these specimens. This study underscores the importance of post mortem cultivation of neural tissue in all patients with chronic CNS disease. Effect of elevated blood tyrosine on intellectual development of premature infants.

The present research was primarily concerned with the question of whether adverse perinatal experiences, particularly those reducing the oxygen supply, are followed by permanent impairment. Interest in the broad problem of "birth injury" and its consequences has arisen, in part, because there exist a number of defects not completely accounted for either on a genetic basis or as reactions to the psychological environment. These defects range from the serious disorders of cerebral palsy, epilepsy, and mental retardation to a variety of minor difficulties which may include speech defects, difficulty in learning to read, and behavior problems.

No abstract

To evaluate the risk of relapse in children with epilepsy whose anticonvulsant therapy has been withdrawn after prolonged control, we studied 148 such children for 15 to 23 years or until relapse. Forty-one of the 148 patients (28 per cent) had recurrence of seizures; of these, 35 (85 per cent) had relapses within five years of drug withdrawal. Factors associated with an increased risk of relapse were a long duration of epilepsy before control, neurologic dysfunction, and jacksonian seizures or combinations of seizure types. We found no association between risk of recurrence and age at onset of epilepsy, total number of seizures before control, age at discontinuation of therapy, electroencephalographic abnormalities, or family history of epilepsy. We conclude that children who do not have the additional risk factors noted above have an excellent chance of remaining seizure free after the withdrawal of anticonvulsant drugs.