Mucocele is a mucus-containing benign lesion, whose clinical characteristic of slow expansion may lead to erosion and remodeling of the bony sinus walls. When the internal content of the mucocele becomes infected, the lesion is called mucopyocele. The etiology of mucocele formation is multifactorial including inflammation, allergy, trauma, anatomical abnormality, previous surgery, fibrous dysplasia, osteoma, and ossifying fibroma. During the past decades since the introduction of endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS), paranasal sinus mucoceles following ESS have been increasingly reported. However, giant mucopyoceles of the frontal sinus expanding cerebral parenchyma are extremely rare. In this case report, we describe a case of huge frontal sinus mucopyocele compressing left frontal lobe after ESS, which was successfully treated by wide marsupialization via the transnasal endoscopic approach.

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