Cytisine (CYT), a partial agonist of α4β2-nicotinic receptors, has been used for antidepressant efficacy in several tests. Nicotinic receptors have been shown to be closely associated with depression. However, little is known about the effects of CYT on the depression. In the present study, a mouse model of depression, the unpredictable chronic mild stress (UCMS), was used to evaluate the activities of CYT. UCMS caused significant depression-like behaviors, as shown by the decrease of total distances in open field test, and the prolonged duration of immobility in tail suspension test and forced swimming test. Treatment with CYT for two weeks notably relieved the depression-like behaviors in the UCMS mice. Next, proteins related to depressive disorder in the brain region of hippocampus and amygdala were analyzed to elucidate the underlying mechanisms of CYT. CYT significantly reversed the decreases of 5-HT1A, BDNF, and mTOR levels in the hippocampus and amygdala. These results imply that CYT may act as a potential anti-depressant in the animals under chronic stress.

A finite element model of thermal coupling stress field during laser cladding plasma spraying of preset MCrAlY coating was constructed based on the finite element model of temperature field by using the indirect thermal coupling method in ANSYS finite element software. Moreover, stress field during laser cladding was analyzed. Through the constructed model, variation laws of stress field with time during laser cladding and cooling process could be mastered. Based on the stress field, the formation mechanism of cracks in laser cladding coating and influencing factors were further analyzed and some solutions to cracks of laser cladding coating were proposed.

Plasma spraying technique was used to prepare MCrAlY coating on TiAl alloy surface, the coating was treated through the laser remelting process, and then scanning electron microscope (SEM) and X-ray diffractometer (XRD) were used to analyze surface topography and phase composition before and after hot corrosion behavior of the coating. Results indicate that after laser remelting treatment, lamellar structure of the coating disappears with improved compactness and most defects like pores and inclusion eliminated. Plasma sprayed MCrAlY coating can significantly improve hot corrosion property of TiAl alloy, which can be further improved after laser remelting. MCrAlY coating mainly experiences surface oxidation reaction and internal sulfurization reaction during the hot corrosion in the high-temperature molten salt, which mainly generate corrosion products such as Al2O3, Cr2O3, NiO, NiCr2O4, Ni3S2 and CrS.