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Purpose -The purpose of this paper is to propose an objective method for technology forecasting (TF). For the construction of the proposed model, the paper aims to consider new approaches to patent mapping and clustering. In addition, the paper aims to introduce a matrix map and K-medoids clustering based on support vector clustering (KM-SVC) for vacant TF. Design/methodology/approach -TF is an important research and development (R&D) policy issue for both companies and government. Vacant TF is one of the key technological planning methods for improving the competitive power of firms and governments. In general, a forecasting process is facilitated subjectively based on the researcher's knowledge, resulting in unstable TF performance. In this paper, the authors forecast the vacant technology areas in a given technology field by analyzing patent documents and employing the proposed matrix map and KM-SVC to forecast vacant technology areas in the management of technology (MOT). Findings -The paper examines the vacant technology areas for MOT patent documents from the USA, Europe, and China by comparing these countries in terms of technology trends in MOT and identifying the vacant technology areas by country. The matrix map provides broad vacant technology areas, whereas KM-SVC provides more specific vacant technology areas. Thus, the paper identifies the vacant technology areas of a given technology field by using the results for both the matrix map and KM-SVC. Practical implications -The authors use patent documents as objective data to develop a model for vacant TF. The paper attempts to objectively forecast the vacant technology areas in a given technology field. To verify the performance of the matrix map and KM-SVC, the authors conduct an experiment using patent documents related to MOT (the given technology field in this paper). The results suggest that the proposed forecasting model can be applied to diverse technology fields, including R&D management, technology marketing, and intellectual property management. Originality/value -Most TF models are based on qualitative and subjective methods such as Delphi. That is, there are few objective models. In this regard, this paper proposes a quantitative and objective TF model that employs patent documents as objective data and a matrix map and KM-SVC as quantitative methods.

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Although Hif‐2α is a master regulator of catabolic factor expression in osteoarthritis development, Hif‐2α inhibitors remain undeveloped. The aim of this study was to determine whether Cirsium japonicum var. maackii (CJM) extract and one of its constituents, apigenin, could attenuate the Hif‐2α‐induced cartilage destruction implicated in osteoarthritis progression. In vitro and in vivo studies demonstrated that CJM reduced the IL‐1β‐, IL‐6, IL‐17‐ and TNF‐α‐induced up‐regulation of MMP3, MMP13, ADAMTS4, ADAMTS5 and COX‐2 and blocked osteoarthritis development in a destabilization of the medial meniscus mouse model. Activation of Hif‐2α, which directly up‐regulates MMP3, MMP13, ADAMTS4, IL‐6 and COX‐2 expression, is inhibited by CJM extract. Although cirsimarin, cirsimaritin and apigenin are components of CJM and can reduce inflammation, only apigenin effectively reduced Hif‐2α expression and inhibited Hif‐2α‐induced MMP3, MMP13, ADAMTS4, IL‐6 and COX‐2 expression in articular chondrocytes. IL‐1β induction of JNK phosphorylation and IκB degradation, representing a critical pathway for Hif‐2α expression, was completely blocked by apigenin in a concentration‐dependent manner. Collectively, these effects indicate that CJM and one of its most potent constituents, apigenin, can lead to the development of therapeutic agents for blocking osteoarthritis development as novel Hif‐2α inhibitors.