Chronic obstructive pulmonary disease (COPD) is characterized by a progressive condition of small airway obstruction, chronic bronchitis and emphysema, representing a leading cause of death worldwide. 1 Although oxidative stress, immunity and inflammation, apoptosis, metaplastic epithelial lesions, mucus hypersecretion and fibrosis in both airways and lungs are hallmarks of this disease, 1,2 the exact pathogenesis of COPD remains unclear. To date, more than 100 kinds of RNA modifications have been identified in living organisms. 3 Certain types of RNA modifications in eukaryotic mRNA, such as 5-methylcytosine (m5C),
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