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1 가천대학교의과대학약리학교실길병원임상시험센터, 2 현성바이탈생명과학연구원, 3 가천대학교의과대학이길여암 · 당뇨연구원, 4 성균관대학교의과대학 약리학교실 서 론 2007년 Ohsawa et al. [1]은 흰쥐 뇌조직에 허헐-재 관류로 생성된 활 성산소(reactive oxygen species, ROS)에 의한 뇌조직 손상이 수소(H2) 흡입으로 억제되었고, 이어 수소는 ROS 중 반응성이 가장 높은 Hydroxyl Radical (HO·)만을 특이적으로 제거함을 관찰하고 수소의 항 산화작용을 보고하였다. 이후 수소가 녹아 있는 수소수 음용에 의해 서도 동물에서 실험적으로 유발된 ROS가 관여하는 각종 질환[2] 및 PURPOSE:This study aimed to investigate whether hydrogen (H2) water drinking reduced oxidative damage products (8-hydroxy-2-deoxyguanosine [8-oxo-dG], malondialdehyde [MDA], L-lactate) produced in blood after exercise-induced oxidative stress.METHODS: Men (n=7) and women (n=8) (systolic blood pressure [BP]: 90-150 mmHg, diastolic BP: 60-100 mmHg) were recruited. Exercise was performed for 20 minutes (8 km/hr) using treadmill. Placebo or test group drunk water and hydrogen water (1.2-1.5 ppm, 1,000 mL), respectively, right after exercise. Three days after, the same experiment was performed in the cross-over manner. Blood samples were obtained 30 minutes before exercise, right after exercise, and 30, 60, 120 minutes after exercise. 8-oxo-dG, MDA and L-lactate in serum were determined using ELISA kit. RESULTS:The blood levels of 8-oxo-dG were significantly increased after exercise (from 381±9.4 to 524±14.9 ng/mL for male; from 367±13.5 to 509±10.7 ng/mL for female). In the placebo group, the increased 8-oxo-dG at each time was not significantly different from the peak level induced by the exercise except that at 120 minutes in female. In the test group, its levels at each time were significantly lower than that in the peak level. The effect of hydrogen water was more pronounced in female than in male. The results obtained with MDA were quite similar to those with 8-oxo-dG. The L-lactate levels were not significant statistically in both groups. CONCLUSIONS:The data suggest that the one time drinking of hydrogen water may suppress the exercise-induced oxidative stress.

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