No abstract

Analogues or isosteres of α,γ-diketoacid (DKA) 1a show potent inhibition of hepatitis C virus (HCV) NS5B polymerase through chelation of the two magnesium ions at the active site. The anti-HCV activity of the flavonoid quercetin (2) could partly be attributed to it being a structural mimic of DKAs. In order to delineate the structural features required for the inhibitory effect and improve the anti-HCV potency, two novel types of quercetin analogues, 7-O-arylmethylquercetins and quercetin-3-O-benzoic acid esters, were designed, synthesized and evaluated for their anti-HCV properties in cell-based assays. Among the 38 newly synthesized compounds, 7-O-substituted derivative 3i and 3-O-substituted derivative 4f were found to be the most active in the corresponding series (EC50 = 3.8 μM and 9.0 μΜ, respectively). Docking studies suggested that the quercetin analogues are capable of establishing key coordination with the two magnesium ions as well as interactions with residues at the active site of HCV NS5B.

No abstract

Abstract. The optimized tube's structure of the self-design ozone generator was made with the double dielectric inner electrode and small metal cones were embedded in the outside electrode. This ozone generator was used for the degradation of phenol in wastewater. The research was studied from ozone gas flow rate, reaction time, the initial pH and concentration of the phenol in wastewater. In addition, the article also discusses the reaction mechanism of ozone degraded the phenol in wastewater. The results illustrate that the ozone concentration of self-design ozone generator under the pure oxygen flux (1.0 L/min) were 7.06 mg/L, compared with the unoptimized ozone, the optimized ozone generator's efficiency was improved 56.89%; the phenol removal rate was increased as the initial pH increased in wastewater, when pH was 12, the phenol removal rate was 80.17%; GC-MS analysis was adopted to analyze and determine the phenol intermediates. The results illustrate that the major oxidation degradation products of phenol may be p-benzoquinone benzenequinone, 4-cyclopentene-1, 3-dione and diacetone alcohol.

No abstract