Purpose: Statin therapy has been shown to prevent major vascular events in a wide range of individuals, but the risk of intracerebral hemorrhage (ICH) from statin use is unclear. We aimed to determine the ICH risk since statin initiation for older patients. Methods: Based on 2011-2020 year data from the Yinzhou Regional Health Care Database, patients aged 50 years or older who have no history of ICH and statin use were included in the framework of target trial emulation, and then were categorized as statin initiators and non-initiators according to their initial statin assignment during 3-month recruitment periods. The statin initiators and non-initiators in each emulated trials were matched by using propensity score and then were stacked together. Cox proportional hazards model was used to estimate the association between ICH risk and statin treatment. Results: With a median follow-up of 7.75 (interquartile range 6.75-8.75) years, 37,659 statins initiators and their 1:1 matched non-initiators were analysed where the hazard ratio of ICH between statin initiators and non-initiators were 1.09 (95% confidence interval: 0.92–1.29). The results are consistent across several subgroups and sensitivity analyses. Conclusions: no association was found between ICH risk and statin use among older patients without prior ICH, suggesting no need to avoid potential statin prescribing due to concerns of evaluated ICH risk.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.