Rare bleeding disorders are caused by genetic mutations in the genes required for blood coagulation. Haemophilia A and B are caused by deficiencies of factor VIII (FVIII) and factor IX (FIX), respectively. Together, they have a prevalence of 1 in 3333 at birth. 1 Diagnosis and treatment vary widely throughout the world, mostly reflecting the socioeconomic status of the countries. In low-income countries, most patients are undiagnosed, and many die prematurely due to the lack of treatment.
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