SENC and SPAMM tagging Cardiac Magnetic Resonance (CMR) are specifically optimized for acquisition before contrast injection and tuned to the end-systolic phase. While SPAMM tagging is a non-quantitative approach that indirectly derives functional motion from the displacement of the saturated tags in the myocardium, SENC directly computes myocardial tissue compression (strain) in percentage units. Furthermore, SENC quantitation pipeline bypasses the signal intensity map that exhibits the decay of the embedded strain measurements. In this study, we examine both SPAMM and SENC post-Gd measurements to specifically indicate the effect of the variable RF pulse train tuned to target tissue T1.

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Multi-Contrast single breath-hold acquisition for cardiac MRI is highly desirable but is rate-limited by the need for a dedicated pre-scan per each acquisition. We revisit the notion of the necessary conditions for repeated preparation calibration steps, with the intent of loosening or selectively bypassing them in consecutive scan acquisitions. Under matched geometric conditions that account for sensitivities especially to off-resonance, we propose a simple bSSFP-SPGR based dual-acquisition method with a single intensive Cine calibration followed by a truncated SPGR calibration. This approach is demonstrated as Cine-Tag SSFP-SPGR CMR method that allows for one breath-hold functional acquisition of both scan sequences.