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A new class of azolyl pyrimidines linked by diamino sulfone moiety was prepared and studied their antimicrobial activity. Chloro‐substituted and nitro‐substituted thiazolyl pyrimidines (9c and 9e) showed excellent antibacterial activity against Bacillus subtilis, while imidazolyl pyrimidines (10c and 10e) exhibited promising antifungal activity against Aspergillus niger.

The bis(oxazolyl and/or thiazolyl)hydrazines were prepared, and their anti‐allergic activity was studied. All the compounds displayed variable extent of anti‐allergic activity on immunoglobulin E/silver‐stimulated RBL‐2H3 cells at 50 and 100 μM concentrations. The unsubstituted and chlorosubstituted compounds showed higher activity than those having methyl substituent. Compounds 9c and 10c do not cause cytotoxicity of the cells at 50 and 100 μM and also significantly inhibit β‐hexosaminidase release stimulated by immunoglobulin E/silver at 50 and 100 μM.

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in Wiley Online Library (wileyonlinelibrary.com).(1) The benzoxazolyl/benzothiazolyl/benzimidazolyl pyrimidines were prepared under ultrasonication in the presence of pyridine/dimethylaminopyridine and triethylamine. (2) Better yields were recorded in 4-(N,N-dimethylamino)pyridine and Et 3 N. (3) The presence of electron withdrawing chloro, bromo, and nitro substituents enhanced antimicrobial activity (13c, 13e, 14e: minimum inhibitory concentration = 6.25 μg/well against Bacillus subtilis; 13e, 14e: minimum inhibitory concentration = 6.25 μg/well against Aspergillus niger).