This paper shows the development of a methodology for the optimization of a hybrid generation system applied in airports. First, the renewable resources available in the area are characterized, the commercial demand profile of electricity consumption is obtained, and the system configuration is proposed. Later, we proceed to the optimization, where the simulation tool HOMER is used for this purpose. The software can determine the net present cost (NPC) and the cost of energy (COE) of different combinations. With the information obtained, it is possible to find the optimal combination of components to satisfy the load demand at the most affordable cost. The proposed methodology is applied to the General Heriberto Jara Corona International Airport, with the purpose of reducing the costs of electric energy consumption and greenhouse gas (GHG) emissions, considering the aeronautical physical easements established by the International Civil Aviation Organization (ICAO). Finally, the profitability of the optimized renewable system is evaluated, thus contributing to sustainable development of the airport.