A review was made of the medical records of 76 patients with uterine myomas during pregnancy with the aim of studying the time and method of diagnosis, symptomatology, treatment, and outcome of pregnancy. In 11 patients (15%) myomectomy was performed during pregnancy. The frequency of abortion was 18% in patients treated both conservatively and with myomectomy. Myomectomy during pregnancy is discouraged in the literature. In cases where conservative treatment cannot be practised it seems that the risk of spontaneous abortion during pregnancy is not significantly increased when myomectomy is performed.

The object of this investigation was to evaluate in the long-term the risk of malignancy occurring in the larynx of patients with dysplasia in the laryngeal epithelium. Over an 8-year period, 1974-82, 170 patients underwent microlaryngoscopic examination of the larynx including biopsy, showing hyperplasia and/or keratosis with or without dysplasia in the laryngeal epithelium. Of these, 147 patients were examined, on an average, 5 years and 4 months later. All histological specimens were reviewed by the same pathologist. Of the patients initially showing mild dysplasia, 7.8% developed aggravation while 55.6% of the patients displaying moderate dysplasia had developed severe dysplasia or carcinoma. 93.2% were smokers. It is concluded that all patients with atypia in the laryngeal epithelium should be observed at regular intervals, but special attention should be given to patients showing moderate dysplasia or worse.

Angiosarcomas are rare tumors, and primary pulmonary location has only been reported in very few cases. In the present report a patient with severe, intractable hemoptysis, demanding pneumonectomy, was found to have a single, small angiosarcoma eroding a large bronchus. No sign of tumor-spread to other organs was detected. A review is made of previous reports of angiosarcomas of the lung, and the differential diagnoses are discussed.

Two cases of highly malignant tumors, one originating in the sigmoid colon and the other in the rectum, are presented. Both tumors showed light microscopic, electron microscopic, and immunohistochemical evidence of multidirectional differentiation. The tumors were composed mainly of undifferentiated cells, but focally merging into areas with adenocarcinomatous and squamous differentiation. Ultrastructurally and histochemically, a predominant endocrine differentiation was present in the undifferentiated areas of the tumors. These two cases lend further support to the recent concept of a pluripotential stem cell in the mucosa of the gastrointestinal tract capable of differentiation in several directions.