This report describes seven deaths caused by angioedema of the tongue related to angiotensin converting enzyme (ACE) inhibitors. These seven cases were received in our office between 1998 and 2000. In that time frame we performed approximately 2000 autopsies. The cases involved African-American mean and women, aged 51 to 65 years, all of whom had been prescribed an ACE inhibitor for the treatment of hypertensive heart disease. In each case, the external examination revealed markedly swollen tongues. The autopsies confirmed massive tongue swelling due to angioedema, and some patients also had swelling of the lips, pharynx, and larynx. Toxicologic analyses on postmortem blood samples were negative for ethanol and drugs of abuse. Although oral and pharyngeal swelling related to angioedema is well known in the clinical literature, its fatal potential has rarely been described.

Limited water resources in the arid southwestern USA have created greater interest on the part of municipalities to utilize nonpotable waters in urban areas. Research was conducted to assess the feasibility of using a perched saline aquifer as an alternative irrigation source for turfgrass. Two line‐source irrigation gradients, one using municipal water with an EC of ≈ 1.1 dS m−1 and the other using saline aquifer water blended with municipal water to an EC of 6.0 dS m−1, were established to impose a salinity and/or water deficit gradient on tall fescue (Festuca arundinacea Schreb. ‘Monarch’) and an improved common bermudagrass (Cynodon dactylon L. ‘Numex Sahara’). Yield was found to be highly correlated with actual evapotranspiration (ETa) (r = 0.92, P < 0.001 for bermudagrass; r = 0.83, P < 0.001 for tall fescue), regardless of how the stress was imposed. Relative ETa (ratio of ETa to maximum ETa under municipal irrigation) values as a function of the summation of the leaf‐to‐air temperature differences also indicated no distinguishable change in stress response based on water quality (r = 0.94, P < 0.001 for tall fescue; r = 0.86, P <0.001 for bermudagrass). Relative turf color and percent cover remained unchanged if the ratio of irrigation volume to potential evapotranspiration (I/ETo) remained above species‐specific threshold values of 0.80 for tall fescue and 0.65 for bermudagrass. Below these thresholds, cover and color declined linearly, with differences due to water quality treatment in tall fescue but with no differences due to water quality treatment in bermudagrass.

Many studies have been published regarding suicidal hanging deaths, and most forensic pathologists and coroners are very familiar with such causes of death. Forensic pathologists are challenged over their rulings regarding manner of death in part because the general public has a limited scope of knowledge. One such challenge centers on the question of whether a hanging can be a suicide if the individual is not fully suspended. The authors designed a retrospective study to review suspension in hangings and to analyze other criteria used to help in deciding manner of death. We examined 229 suicidal hanging deaths over an 11-year period (1997 through early 2009) using the data from two separate jurisdictions in Ohio. In conclusion, we found that the vast majority (83.4%) of people who hanged themselves were found partially suspended. Among other criteria analyzed, only the presence of petechial hemorrhages and acute neck injury was statistically significant.

Skeletal remains of a domestic pig were assessed for relative distribution of amitriptyline, citalopram, and metabolites. Following acute exposure and outdoor decomposition for 2 years, drugs and metabolites were analyzed in 13 different bones. Bones were pulverized following a simple wash procedure, and drugs were extracted by passive incubation in methanol, followed by solid-phase extraction. Samples were analyzed by ultra-high performance liquid chromatography (UHPLC) and confirmed with gas chromatography-mass spectrometry. The Kruskall-Wallis test showed that bone type was a main effect with respect to drug level for all analytes, with levels varying from 33- to 166-fold. Ratios of levels of drug to that of the corresponding metabolite were less variable, varying roughly one- to eightfold. This suggests limitations in the interpretive value of drug measurements in bone and that relative levels of drug and metabolites should be further investigated in terms of forensic value.