Various dietary supplements are claimed to have cutaneous anti-aging properties; however, there are a limited number of research studies supporting these claims. The objective of this research was to study the effectiveness of collagen hydrolysate (CH) composed of specific collagen peptides on skin biophysical parameters related to cutaneous aging. In this double-blind, placebo-controlled trial, 69 women aged 35-55 years were randomized to receive 2.5 g or 5.0 g of CH or placebo once daily for 8 weeks, with 23 subjects being allocated to each treatment group. Skin elasticity, skin moisture, transepidermal water loss and skin roughness were objectively measured before the first oral product application (t0) and after 4 (t1) and 8 weeks (t2) of regular intake. Skin elasticity (primary interest) was also assessed at follow-up 4 weeks after the last intake of CH (t3, 4-week regression phase). At the end of the study, skin elasticity in both CH dosage groups showed a statistically significant improvement in comparison to placebo. After 4 weeks of follow-up treatment, a statistically significantly higher skin elasticity level was determined in elderly women. With regard to skin moisture and skin evaporation, a positive influence of CH treatment could be observed in a subgroup analysis, but data failed to reach a level of statistical significance. No side effects were noted throughout the study.

Dietary consumption of food supplements has been found to modulate skin functions and can therefore be useful in the treatment of skin aging. However, there is only a limited number of clinical studies supporting these claims. In this double-blind, placebo-controlled study, the effectiveness of the specific bioactive collagen peptide (BCP) VERISOL® on eye wrinkle formation and stimulation of procollagen I, elastin and fibrillin biosynthesis in the skin was assessed. A hundred and fourteen women aged 45-65 years were randomized to receive 2.5 g of BCP or placebo, once daily for 8 weeks, with 57 subjects being allocated to each treatment group. Skin wrinkles were objectively measured in all subjects, before starting the treatment, after 4 and 8 weeks as well as 4 weeks after the last intake (4-week regression phase). A subgroup was established for suction blister biopsies analyzing procollagen I, elastin and fibrillin at the beginning of the treatment and after 8 weeks of intake. The ingestion of the specific BCP used in this study promoted a statistically significant reduction of eye wrinkle volume (p < 0.05) in comparison to the placebo group after 4 and 8 weeks (20%) of intake. Moreover a positive long-lasting effect was observed 4 weeks after the last BCP administration (p < 0.05). Additionally, after 8 weeks of intake a statistically significantly higher content of procollagen type I (65%) and elastin (18%) in the BCP-treated volunteers compared to the placebo-treated patients was detected. For fibrillin, a 6% increase could be determined after BCP treatment compared to the placebo, but this effect failed to reach the level of statistical significance. In conclusion, our findings demonstrate that the oral intake of specific bioactive collagen peptides (Verisol®) reduced skin wrinkles and had positive effects on dermal matrix synthesis.

Evelle can potentially improve visible signs of cutaneous ageing.

Characterization of the skin's natural state is very important for understanding skin functions and describing disturbances of skin function. In the field of cosmetics and dermatologicals the natural pH of the skin surface plays an important role in the development of products with a skin neutral pH. In a multicenter study the natural pH of the skin surface (exception of underarm and genital areas), was to be measured. It was to be determined whether gender‐specific differences in the pH occur. The skin surface pH was measured on the inside of the forearms in 222 volunteers (147 female, 75 male) using the skin pH meters of the respective institutes. The pH was measured in triplicate on adjacent areas 24 h after the last contact of the measuring site with water, topical applications and an intensive washing procedure. The values of the skin surface pH were 4.9 (arithmetic mean). The 95% interval was between 4.1 and 5.8. The pH on the forearm of the male volunteers was slightly lower than that of the females. The difference was statistically significant (p < 0.01; 4.8 to 5.0). The authors suggest that the GDCh recommendations for the claims »skin neutral pH«, »ideal pH« or »skin‐friendly pH« should be revised and propose a pH range of 4.1 to 5.8 for the main body areas excluding the underarm and genital areas.

Eskimo Skin Care, an oral preparation rich in natural stable fish oil, can improve skin elasticity.