This study made it possible to demonstrate that Saba senegalensis has hypoglycemic and anti-hyperglyvemic effects in mice. The aqueous extract of Saba senegalensis from 75 to 250 mg / Kg bw causes a dose-dependent hypoglycemia ranging from 4.84 to 34.62% (p <0.01-0.05), in normoglycemic mice, 60 minutes after treatment. The Glucose-Induced Hyperglycemia Orally (OPGH) test showed that in the presence of Saba senegalensis aqueous extract at a concentration between 75 and 250mg/Kg bw, the glucose-induced hyperglycemic peak (3g/Kg bw) is reduced from 26.49 to 71.77% (p < 0.01-0.05), 30 minutes after treatment. Oral administration of the aqueous extract of this plant in doses up to 5000 mg / Kg bw resulted in no deaths in mice during two weeks of observation.   

Les cryptococcoses sont des maladies opportunistes du sida qui entraînent un fort taux de mortalité chez les personnes vivant avec le VIH (PVVIH). En Côte-d’Ivoire, leur traitement est difficile à cause des résistances, de la toxicité et du coût élevé des antifongiques. Cette étude a été menée dans le but de rechercher, dans la pharmacopée ivoirienne, des phytomolécules aux propriétés antifongiques capables de traiter à moindre coût les cryptococcoses neuroméningées des immunodéprimés. Les fractions hexane, dichlorométhane, acétate d’éthyle et aqueuse finale ont été extraites de Hugonia platysepala. Ces fractions ont été testées in vitro sur Cryptococcus neoformans, par les méthodes de dilution en milieu liquide et de diffusion en milieu solide. La fraction acétate a été la plus active avec une CMI de 0,78 mg/ml, une CI50 de 0,52 mg/ml et une CMF de 25 mg/ml contre Cryptococcus neoformans. Cette fraction a une activité fongicide plus élevée que celle de l’extrait hydroalcoolique de l’amphotéricine B et du fluconazole qui sont les antifongiques prescrits aux PVVIH. Le screening phytochimique a révélé que cette fraction acétate contient des terpènes, des polyphénols, des tanins et des quinones qui seraient responsables de ses propriétés pharmacologiques antifongiques. L’utilisation de Hugonia platysepala comme médicament traditionnel amélioré est donc un atout dans le traitement des cryptococcoses chez les immunodéprimés.

Cassia sieberiana is a tree of 8 to 10 meters in height, used to treat various diseases including malaria, dysmenorrhea and many others. Our objective is the scientific valorisation of Cassia sieberiana, a plant used in therapy in Ivory Coast, by evaluating the anti-inflammatory activity of the bark of the root of Cassia sieberiana. To do this, the phytochemical study was carried out in order to determine the main chemical constituents with therapeutic potential, then the acute toxicity by gavage and intraperitoneal injection were carried out and finally the anti-inflammatory activity was verified. The phytochemical study revealed the presence of sterols, polyterpenes, polyphenols, flavonoids, catechic tannins, saponosides and alkaloids. As for the toxicity study, it allowed us to determine by per os route an LD50 > 5000 mg/kg PC, and by IP an LD50 = 524, 807 mg/kg PC graphically and by calculation an LD50 = 400 mg/kg PC. The anti-inflammatory activity of the aqueous extract of Cassia sieberiana at a dose of 200 mg/kg CP is higher than that of diclofenac at a dose of 10 mg/kg CP from the 3rd to the 6th hour of the experiment. Cassia sieberiana is non-toxic by oral administration but toxic by intraperitoneal injection. Cassia sieberiana also has anti-inflammatory activity.

Aims: The aqueous extract of cashew apple cakes, rich in molecules of pharmacological interest, could be used against many diseases. Thus, the aim of the present work is to evaluate its hepatoprotective activity in rats and mice.  Methodology: Two batches of rats weighing between 200 and 300 grams, with five rats per batch, were pretreated for eleven days with the aqueous extract of cashew apple cakes at concentrations ranging from 150 to 300 mg.Kg-1 bw, then intoxicated with paracetamol at 2 g.Kg-1 bw, for three days. The blood of these rats was collected and submitted to biochemical analyses.  Two batches of mice weighing between 20 and 30 grams, with five mice per batch, were pretreated with the same test substance at concentrations also ranging from 150 to 300 mg.Kg-1 bw, then intoxicated with paracetamol before receiving phenobarbital. Afterwards, their sleep time was evaluated. Results: In rats, paracetamol intoxication materialized by the increase in serum ALT activity ranging from 109±5.19 to 571±20.28 IU.L-1 and that of AST ranging from 144±5.77 to 428±14.19 IU.L-1. Similarly, direct bilirubin increased from 0 to 1.08± 0.58 mg.dl-1. These increases in transaminase activity and bilirubin levels were significantly decreased in rats pretreated with the aqueous extract of cashew apple cake. In mice, the phenobarbital test showed a 29.82 to 38.59% decrease in sleep time in mice pretreated with the aqueous extract of cashew apple cakes. Conclusion: The aqueous extract of cashew apple cakes influencing biochemical parameters such as ALT, AST, bilirubin and sleep time, could therefore be used in the prevention of liver diseases, in traditional medicine.

Background: Sarcocephalus latifolius, a plant of the Rubiaceae family, is found exclusively in tropical Africa, more particularly in sub-Saharan West Africa, stretching from Senegal to Zaire, but is also found as far east as Sudan (Sudan-Guinean zone). The leaves of this plant are used in traditional African medicine to treat numerous pathologies such as infertility. Aims/Objective: The present study aims to evaluate the effects of the aqueous extract of Sarcocephalus latifolius leaves on sexual parameters in male rats. Methods: The sexual parameters (latency of the mating position, latency of intromission, latency of ejaculation and mean copulation interval) were assessed by the classical method by administering distilled water, sildenafil citrate (reference molecule) called Viagra at the dose of 5 mg/kg of body weight and the aqueous extract of Sarcocephalus latifolius leaves at the dose of 1000 mg/kg of body weight per day for eight days to three batches of male rats respectively. These parameters were determined over a period of thirty minutes. Results: The results obtained show that the aqueous extract of Sarcocephalus latifolius leaves at a dose of 1000 mg/kg of body weight significantly (P < .001) decreases the latency time of mating position and the latency time of intromission, whereas this extract significantly (P < .001) increases the latency time of ejaculation and the average copulation interval. Conclusion: Aqueous extract of Sarcocephalus latifolius leaves has aphrodisiac properties which are due to sterols, flavonoids and saponosides.