Increased rates of overweight globally highlight the need for effective weight management tools. Unfortunately, the complexity of weight management creates challenges and successful interventions backed by well‐controlled studies are lacking. The purpose of this study was to test a blend of natural compounds along with a diet and exercise program for the ability to support healthy weight loss in humans.Sixty‐nine subjects (47 Women (W) and 22 Men (M)) average age 43.9 ± 9.8 years and an average Body Mass Index (BMI) of 30.6 ± 3.4 were instructed to follow the diet, exercise and supplement program for 2 weeks. 91% of subjects lost weight, average weight loss after two weeks was −3.8 ± 3.1 lbs (−3.0 ± 2.9 lbs W; −5.4 ± 3.0 lbs M) and average fat loss of −1.4 ± 2.3% (−1.3 ± 2.4% W; −1.6 ± 1.9% M)(all changes p < 0.05). Although men lost more weight than women, women experienced greater changes in body measurements. Women exhibited statistically significant reductions in waist, hip, arm and ankle circumferences while no changes were recorded in men. No adverse events were reported and laboratory values were within normal limits.A weight management program made up of a unique blend of natural compounds, a diet and an exercise regime, led to successful reductions in body weight and % body fat within 2 weeks. These positive findings warrant further investigation including a longer term intervention and a randomized placebo controlled trial. Research was supported by Nu Skin Enterprises, Provo, Utah
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