Environmental exposure to active pharmaceutical ingredients (APIs) can have negative effects on the health of ecosystems and humans. While numerous studies have monitored APIs in rivers, these employ different analytical methods, measure different APIs, and have ignored many of the countries of the world. This makes it difficult to quantify the scale of the problem from a global perspective. Furthermore, comparison of the existing data, generated for different studies/regions/continents, is challenging due to the vast differences between the analytical methodologies employed. Here, we present a global-scale study of API pollution in 258 of the world’s rivers, representing the environmental influence of 471.4 million people across 137 geographic regions. Samples were obtained from 1,052 locations in 104 countries (representing all continents and 36 countries not previously studied for API contamination) and analyzed for 61 APIs. Highest cumulative API concentrations were observed in sub-Saharan Africa, south Asia, and South America. The most contaminated sites were in low- to middle-income countries and were associated with areas with poor wastewater and waste management infrastructure and pharmaceutical manufacturing. The most frequently detected APIs were carbamazepine, metformin, and caffeine (a compound also arising from lifestyle use), which were detected at over half of the sites monitored. Concentrations of at least one API at 25.7% of the sampling sites were greater than concentrations considered safe for aquatic organisms, or which are of concern in terms of selection for antimicrobial resistance. Therefore, pharmaceutical pollution poses a global threat to environmental and human health, as well as to delivery of the United Nations Sustainable Development Goals.

Mining operations have released measurable levels of geogenic trace metals (e.g. Cd, Cr, Pb), metalloids (e.g. As, Se), and anthropogenic chemicals (e.g. CN -, Hg) into surrounding sediments. Abandoned mining sites in hyperarid climates has not been the focus of much research compared to wet and temperate areas. Research has focused on historical mining sites in semiarid and wetter regions in the United States, south pacific and Europe. Those areas have obvious risks associated with them including aqueous phase mobilization as a result of abundant precipitation. However, many mining areas in the American Southwest and aboard are located in hyperarid regions and viewed as not having a potential for mobilization of contaminants. Seasonal storm events can mobilize sediments containing contaminates beyond a small, localized area and into the wider environment. Literature indicates that arid and hyperarid mining regions have not been studied as extensively as those in wetter climates.

Dry lakes, or playas, in the American Southwest have become important locations for alternative energy solar electric generation systems. Many of these playas have not been investigated for past environmental conditions prior to their development, causing alterations to the shallow sediment profile and altering subsurface chemical and physical data important to recent geologic and hydrologic histories of these areas. Recent studies of these features commonly have focused on surficial data with little or no subsurface geologic data to delineate wet and dry cycles of playa lakes. Many of the playa margins are covered with a surficial layer of alluvial and/or aeolian sands varying in thickness, which could interfere with correct interpretations of data gathered only on the surface material on these lands. Over the past 13,000 years Ivanpah Dry Lake has had at least three episodes of lake highstands up to ~10m in response to climate changes, based on data in this study with the oldest episode dates to ~13,000 cal yrs BP. This study has a link to other sites as many other playas are slated for energy development and could endure subsurface data alteration during site reworking and occupation, resulting in a loss in their collective historical geologic and hydrologic records if more complete studies of important sites are not carried out before developments begin.

Abstract:Hazardous substances (e.g., toxic elements, oxides of nitrogen, carbon and sulfur) are discharged to the environment by a number of natural and anthropogenic activities. Anthropogenic air pollution commonly contains trace elements derived from contaminants and additives released into the atmosphere during fossil fuel combustion (automobiles, power generation, etc.) as well as physical processes (e.g., metal refining, vehicle brake wear, and tire and pavement wear). Analysis of pollutant chemical concentrations in lichens collected across the Las Vegas Valley allows documentation of the distribution of air pollution in the Valley. Analyses of lichen biomass (Buellia dispersa), when compared to windrose diagrams, shows pathways of airborne pollutant transport across the Las Vegas Valley. The west and north sectors of the Las Vegas Valley contained the lowest target contaminates (e.g., Cr, Cu, Co, Pb, Ni) and the highest NO 3 − while the east and south sectors contained the highest levels of target contaminates and lowest NO 3 − . Additionally, metals and NO 3 − detected in the east and south sectors of the valley indicate that air pollution generated in the valley is moving from the south to the north-northeast and across the valley, exiting on the north and south side of Frenchman Mountain.

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